Effects of Mitomycin-C on Spermatogenesis of Mice with Reference to the Dose Relation between Mitomycin-C and X-rays
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Effects of mitomycin-C on spermatogenesis of mice with reference to the dose relation between mitomycin-C and X-rays.
Some of the antibiotics have excited our interest in the field of cancer chemotherapy because of their anti-tumor actions. In this connection it is of particular significance to understand the mechanism of cell-damage under the influence of these agents, since both growth and regression of the tumor are under the control of the mitotic mechanism. Mitomycin-C is one of the antibiotics isolated f...
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Mitomycin C (MC) is a chemically reactive antibiotic derived from Streptomyces caespitosus. The drug selectively inhibits DNA synthesis (2, 15, 29, 34, 39, 40, 43, 44, 49) and degrades cellular DNA but does not affect the synthesis of R N A or protein (31, 33, 40). MC induces bacteriophage production in lysogenic bacteria (23, 29), increases the rate of genetic recombination among mutant forms ...
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Effects of caffeine on L-cells exposed to mitomycin C.
Mouse L-cells were grown in suspension culture and exposed to varying concentrations, from 0.2 to 4 ¿ig/ml,of mitomycin C for periods ranging from 0.5 to 3.5 hr. A plot of cell colony-forming ability versus concentration of mitomycin C for different times of exposure yielded a series of exponential survival curves which were related by the fact that the product of the time of exposure and the ...
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BMY 25282, a newly designed analogue of mitomycin C (MMC), was assessed for its non-cross-resistant cytotoxic and biochemical action against MMC-resistant human colon carcinoma cells. The analogue has an amidine substituted at position 7 of MMC and has a more efficient intracellular activation to its active species than MMC. In this study we demonstrated that BMY 25282 can overcome MMC resistan...
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ژورنال
عنوان ژورنال: Archivum histologicum japonicum
سال: 1969
ISSN: 0004-0681
DOI: 10.1679/aohc1950.30.497